Optical Coherence Tomography Applications in Cardiac Electrophysiology
The goal of the Structure Function Laboratory at Columbia University is to develop optical imaging tools to address unmet clinical needs. Cardiovascular disease is the leading cause of morbidity and mortality in the United States. Progress within the cardiovascular field towards early diagnosis, increased efficacy in therapy and understanding the underlying mechanisms of cardiovascular diseases have been aided in part by advances in medical imaging technologies. Optical coherence tomography (OCT) is a non-invasive imaging modality that provides depth-resolved, high-resolution images of tissue microstructure in real-time. OCT provides subsurface imaging of depths 1-2mm in cardiac tissue with high spatial resolution (10um) in three dimensions and high sensitivity in vivo. Fiber-based OCT systems can be incorporated into catheters to image internal organs. These features have made OCT a powerful tool for cardiovascular imaging, with major contributions to the field of coronary artery disease.
Spectroscopic Optical Coherence Tomography
- Time-frequency analysis to analyze depth resolved spectral characteristics of biological tissue
Structure – Function of the Myocardium
- Development of image processing algorithms to quantify myofiber orientation and correlate the orientation to action potential propagation properties
Translation of Optical Coherence Tomography (OCT) for Anatomical Substrate Guided Radiofrequency Ablation (RFA) Therapy
- Development of image processing algorithms to assess energy delivery to the myocardium by radiofrequency ablation by analysis of optical coherence tomography images
- Optical and mechanical design and prototyping of catheters for imaging in vivo. Our current focus is the development of forward imaging optical coherence tomography catheters to image while in contact with the heart wall in vivo.